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This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
brain-type cannabinoid receptor; CANN6; Cannabinoid receptor 1; cannabinoid receptor 1 (brain); CB1; CB1 cannabinoid receptor; CB1 receptor; CB1A; CB1K5; CB1R; CB-R; central cannabinoid receptor; CNR; Cnr1; HGNC:2159; OTTHUMP00000016839; RP1-23D17.1; seven transmembrane domains; G-protein-coupled receptor; Skr6; SKR6R; striatal cannabinoid receptor type 1 protein
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